Portal de investigación
Gene-Specific Detection Rate of Adenomas and Advanced Adenomas in Lynch Syndrome
Autores de I3PT
Participantes ajenos a I3PT
- Sánchez, A
- Castillo-Iturra, J
- Roos, VH
- Dueñas, N
- Pineda, M
- Moreno, L
- Rodríguez-Alonso, L
- Cajal, TRY
- Piñol, V
- Fernandez, AL
- Salces, I
- Picó, MD
- Rivas, L
- Bujanda, L
- Garzon, M
- Pizarro, A
- de Castro, EM
- Lopez-Arias, MJ
- Poves, C
- Garau, C
- Rodriguez-Alcalde, D
- Herraiz, M
- Alvarez-Urrutia, C
- Dacal, A
- Carrillo-Palau, M
- Cid, L
- Ponce, M
- Barreiro-Alonso, E
- Saperas, E
- Aguirre, E
- Bastiaansen, B
- Ocana, T
- Carballal, S
- Rivero-Sanchez, L
- Ortiz, O
- Daca-Alvarez, M
- Prat-Galito, R
- Bessa, X
- Cubiella, J
- Jover, R
- Rodríguez-Moranta, F
- Balmaña, J
- Brunet, J
- Castells, A
- Capellá, G
- Ladabaum, U
- Dekker, E
- Moreira, L
- Pellisé, M
- Balaguer, F
Grupos de Investigación
Abstract
BACKGROUND & AIMS: Colonoscopy is expected to reduce colorectal cancer (CRC) incidence in Lynch syndrome (LS) by detecting and removing adenomas. The existence of genespecific differences in adenoma detection has been proposed yet remains insufficiently explored. This study aims to elucidate gene-specific adenoma detection rates and their association with post-colonoscopy CRC (PCCRC), which stands as an important issue in LS surveillance. METHODS: In this multicenter study, we analyzed 1072 LS carriers without prior CRC undergoing surveillance colonoscopy, evaluating adenoma and advanced adenoma (AA) detection rates by gene. The primary outcome was to compare adenoma detection rates in individuals without prior CRC carrying pathogenic variants in MLH1/MSH2 vs MSH6/PMS2. Subgroup analysis was performed to assess the intermediate risk profile in MSH6 carriers relative to MLH1/MSH2 and PMS2 carriers. We compared overall adenoma detection rates, adenoma burden, age at first adenoma occurrence, and 10-year cumulative detection rates. Risk factors for AA and PCCRC were also identified. Multiple testing and multivariate analyses were performed. RESULTS: The adenoma detection rates were similar across the 4 genes. However, MLH1/MSH2 carriers had a higher overall AA detection rate compared with MSH6/PMS2 carriers (14.5% vs 11.9%; P =.04) and showed higher cumulative AA detection rates over 10 years (21.6% vs 19.7%; P 1/4 .04). Subgroup analysis indicated that MSH6 carriers had an intermediate AA detection rate positioned between MLH1/MSH2 carriers and PMS2 carriers. Multivariate analysis indicated that AAs (odds ratio, 2.12; 95% confidence interval, 1.08-4.17; P 1/4 .03) and repeated AA detection (odds ratio, 4.62; 95% confidence interval, 1.70-12.57; P <.01) were independent risk factors for PCCRC. CONCLUSIONS: Carriers of MLH1/MSH2 pathogenic variants are at a higher risk of developing AAs compared with those with MSH6/PMS2 mutations, with MSH6 carriers exhibiting an intermediate risk profile. AAs are an independent risk factor for PCCRC. LS patients with AAs should be identified as high risk and undergo enhanced colonoscopy surveillance.
Datos de la publicación
- ISSN/ISSNe:
- 0016-5085, 1528-0012
- Tipo:
- Article
- Páginas:
- 663-675
- PubMed:
- 40315961
- Enlace a otro recurso:
- www.scopus.com
Gastroenterology W B SAUNDERS CO-ELSEVIER INC
Citas Recibidas en Scopus: 3
Documentos
- No hay documentos
Filiaciones
Keywords
- Lynch Syndrome; Adenomas; Colonoscopy; Colorectal Cancer; Hereditary Colorectal Cancer
Financiación
Cita
Sánchez A,Castillo J,Roos VH,Dueñas N,Pineda M,Moreno L,Rodríguez L,Cajal TRY,Llort G,Piñol V et al. Gene-Specific Detection Rate of Adenomas and Advanced Adenomas in Lynch Syndrome. Gastroenterology. 2025. 169. (4):p. 663-675. DOI: 10.1053/j.gastro.2025.03.042.
Sánchez A,Castillo J,Roos VH,Dueñas N,Pineda M,Moreno L,Rodríguez L,Cajal TRY,Llort G,Piñol V,Fernandez AL,Salces I,Picó MD,Rivas L,Bujanda L,Garzon M,Pizarro A,de Castro EM,Lopez MJ,Poves C,Garau C,Rodriguez D,Herraiz M,Alvarez C,Dacal A,Carrillo M,Cid L,Ponce M,Barreiro E,Saperas E,Aguirre E,Bastiaansen B,Ocana T,Carballal S,Rivero L,Ortiz O,Daca M,Prat R,Bessa X,Cubiella J,Jover R,Rodríguez F,Balmaña J,Brunet J,Castells A,Capellá G,Ladabaum U,Dekker E,Moreira L,Pellisé M,Balaguer F. Gene-Specific Detection Rate of Adenomas and Advanced Adenomas in Lynch Syndrome. Gastroenterology. 2025. 169. (4):p. 663-675. IF:25,900. (1).