Portal de investigación
Disrupted network switching in euthymic bipolar disorder: Working memory and self-referential paradigms
Autores de I3PT
Participantes ajenos a I3PT
- Sole, B
- Montejo, L
- Torrent, C
- Martinez-Aran, A
- Harrison, BJ
- Vieta, E
Grupos de Investigación
Abstract
Background: Patients with bipolar disorder (BD) frequently suffer from neurocognitive deficits that can persist during periods of clinical stability. Specifically, impairments in executive functioning such as working memory and in self-processing have been identified as the main components of the neurocognitive profile observed in euthymic BD patients. The study of the neurobiological correlates of these state-independent alterations may be a prerequisite to develop reliable biomarkers in BD.Methods: A sample of 27 euthymic BD patients and 25 healthy participants (HC) completed working memory and self-referential functional Magnetic Resonance Imaging (fMRI) tasks. Activation maps obtained for each group and contrast images (i.e., 2-back > 1-back/self > control) were used for comparisons between patients and HC.Results: Euthymic BD patients, in comparison to HC, showed a higher ventromedial prefrontal cortex activation during working memory, a result driven by the lack of deactivation in BD patients. In addition, euthymic BD patients displayed a greater dorsomedial and dorsolateral prefrontal cortex activation during self-reference processing. Limitations: Pharmacotherapy was described but not included as a confounder in our models. Sample size was modest. Conclusion: Our findings revealed a lack of deactivation in the anterior default mode network (aDMN) during a working memory task, a finding consistent with prior research in BD patients, but also a higher activation in frontal regions within the central executive network (CEN) during self-processing. These results suggest that an imbalance of neural network dynamics underlying external/internal oriented cognition (the CEN and the aDMN, respectively) may be one of the first reliable biomarkers in euthymic bipolar patients.
Datos de la publicación
- ISSN/ISSNe:
- 0165-0327, 1573-2517
- Tipo:
- Article
- Páginas:
- 552-560
- PubMed:
- 36202301
- Enlace a otro recurso:
- www.scopus.com
JOURNAL OF AFFECTIVE DISORDERS ELSEVIER
Citas Recibidas en Web of Science: 5
Documentos
- No hay documentos
Filiaciones
Keywords
- Bipolar disorder; Functional neuroimaging; Self concept; Memory; Short-term; Default mode network