Portal de investigación
Survival and Disease-Free Survival by Breast Density and Phenotype in Interval Breast Cancers
Fecha de publicación:
Autores de I3PT
Participantes ajenos a I3PT
- Sala, M
- Domingo, L
- Louro, J
- Tora-Rocamora, I
- Ferrer, J
- Carmona-Garcia, MC
- Barata, T
- Roman, M
- Macia, F
- Castells, X
- CAMISS Study Grp
Abstract
Background: We aimed to evaluate survival and disease-free survival in different subtypes of interval cancers by breast density, taking into account clinical and biological characteristics. Methods: We included 374 invasive breast tumors (195 screen-detected cancers; 179 interval cancers, classified into true interval, false-negatives, occult tumors and minimal-sign cancers) diagnosed in women ages 50-69 years undergoing biennial screening from 2000-2009, followed up to 2014. Breast density was categorized into non-dense (< 25% dense tissue) and mixed dense breasts (>= 25%). Survival curves were generated by the Kaplan-Meier method and compared by the log-rank test. Cox proportional hazard regression models were computed to estimate the adjusted hazard ratios (aHRs) and 95% confidence intervals (95% CIs) for death and recurrences by comparing women with interval and true interval cancers versus women with screen-detected cancers, controlling for tumor and patient characteristics. All analyses were stratified by breast density. Results: Interval cancers were detected in younger women, at more advanced stages, in denser breasts and showed a higher proportion of triple-negative cancers, especially among true interval cancers. Women with interval cancer and non- dense breasts had an aHR for death of 3.40 (95% CI, 0.92-12.62). Women with true interval cancers detected in nondense breasts had the highest adjusted risk of death (aHR, 6.55; 95% CI, 1.37-31.39). Conclusions: Women with true interval cancer in nondense breasts had a higher risk of death than women with screen-detected cancers. Impact: These results support the advisability of routinely collecting information on breast density, both for further tailoring of screening strategies and as a prognostic factor for diagnosed breast cancers. Cancer Epidemiol Biomarkers Prev; 27(8); 908-16. (C) 2018 AACR.
Datos de la publicación
- ISSN/ISSNe:
- 1055-9965, 1538-7755
- Tipo:
- Article
- Páginas:
- 908-916
- PubMed:
- 29853482
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION AMER ASSOC CANCER RESEARCH
Citas Recibidas en Web of Science: 11
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Cita
Sala M,Domingo L,Louro J,Tora I,Bare M,Ferrer J,Carmona MC,Barata T,Roman M,Macia F et al. Survival and Disease-Free Survival by Breast Density and Phenotype in Interval Breast Cancers. Cancer Epidemiol. Biomarkers Prev. 2018. 27. (8):p. 908-916. DOI: 10.1158/1055-9965.EPI-17-0995.
Sala M,Domingo L,Louro J,Tora I,Bare M,Ferrer J,Carmona MC,Barata T,Roman M,Macia F,Castells X,CAMISS GRP. Survival and Disease-Free Survival by Breast Density and Phenotype in Interval Breast Cancers. Cancer Epidemiol. Biomarkers Prev. 2018. 27. (8):p. 908-916. IF:5,057. (1).